Down Syndrome

A Deeper look at Down Syndrome


21 chromosome for DSAccording to recent research, the fundamental functional abnormality in the postnatal Ts65Dn brain may be an imbalance between excitation and inhibition. In addition to a decrease in the number of excitatory synapses and a relative rise in inhibitory synaptic markers in the cortex and hippocampus, multiple studies have revealed that excessive GABA-mediated inhibition inhibits the induction of long-term potentiation in Ts65Dn hippocampus.

    A recent study showed that treatment of Ts65Dn mice with GABA receptor adversaries could rescue defects in explicit learning, recollection and LTP, indicative of increased inhibition. Overall, these functional findings imply that enhanced inhibitory synaptic drive is a typical physiological feature in the Ts65Dn forebrain. We wanted to know what was causing this over-inhibition phenotype at the molecular and cellular levels Researchers carried out a multidisciplinary set of studies to investigate neurophysiology, neurogenesis, and the genetic reasons of altered brain development in the Ts65Dn mouse brain